Cycloguanil-d4 (hydrochloride), CAS [[1189427-23-3]] Preis auf Anfrage
Artikelnummer:
MCE-HY-12784AS
Hersteller Artikelnummer:
HY-12784AS
Alternativnummer:
MCE-HY-12784AS-10MG,MCE-HY-12784AS-1MG
Hersteller:
MedchemExpress
Kategorie:
Biochemikalien
Alternative Synonym:
Chlorguanide triazine-d4 (hydrochloride)
Cycloguanil-d4 (Chlorguanide triazine-d4) hydrochloride is the deuterium labeled Cycloguanil hydrochloride (HY-12784A). Cycloguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 10.8 µM against human DHFR. Cycloguanil hydrochloride blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil hydrochloride inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil hydrochloride also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity[1][2].
