Cycloguanil-d4 (hydrochloride), CAS [[1189427-23-3]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-12784AS
Supplier Catalog Number:
HY-12784AS
Alternative Catalog Number:
MCE-HY-12784AS-10MG,MCE-HY-12784AS-1MG
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
Chlorguanide triazine-d4 (hydrochloride)
Cycloguanil-d4 (Chlorguanide triazine-d4) hydrochloride is the deuterium labeled Cycloguanil hydrochloride (HY-12784A). Cycloguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 10.8 µM against human DHFR. Cycloguanil hydrochloride blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil hydrochloride inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil hydrochloride also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity[1][2].
