5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 µM and 1.34 µM, respectively[1][2].
Molekulargewicht:
311.77
Reinheit:
99.14
CAS Nummer:
[1428-95-1]
Formel:
C12H18ClN7O
Target-Kategorie:
Apoptosis,HIV,Sodium Channel
Anwendungsbeschreibung:
MCE Product type: Reference compound
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