ARS-1323-alkyne is a covalent inhibitor probe that covalently binds to the Switch-II pocket (S-IIP) of the KRAS G12C mutant protein. ARS-1323-alkyne visualizes the covalent modification of KRAS G12C and quantitatively measures the binding efficiency of the inhibitor to the target. ARS-1323-alkyne can be used to validate the target occupancy of KRAS G12C inhibitors and the synergistic mechanism of combination therapy[1].
Molekulargewicht:
569.00
Reinheit:
99.59
CAS Nummer:
[2436544-27-1]
Formel:
C28H27ClF2N6O3
Target-Kategorie:
Ras
Anwendungsbeschreibung:
MCE Product type: Reference compound
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