TBK1/IKKepsilon-IN-5 (compound 1) is an orally active TBK1 and IKKepsilon dual inhibitor, with IC50 values of 1 and 5.6 nM, respectively. TBK1/IKKepsilon-IN-5 enhances the blockade response to PD-1 and induces immune memory in rats when combines with anti-PD-L1. TBK1/IKKepsilon-IN-5 can be used in cancer research, especially in tumour immunity[1].
Molekulargewicht:
513.59
Reinheit:
99.96
CAS Nummer:
[1893397-65-3]
Formel:
C28H31N7O3
Target-Kategorie:
IKK
Anwendungsbeschreibung:
MCE Product type: Reference compound
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