RO4988546 is a negative allosteric modulator (NAM) that targets metabotropic glutamate receptors 2 and 3 (mGlu2, mGlu3). RO4988546 can reduce the binding of [3h]-LY354740 at the positive binding site, while affecting the receptors G protein coupling and intracellular signaling. RO4988546 can be used in the development of antidepressants and cognitive enhancers[1].
Molekulargewicht:
512.38
CAS Nummer:
[911114-85-7]
Formel:
C21H10F6N4O3S
Target-Kategorie:
mGluR
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
