RO4988546 is a negative allosteric modulator (NAM) that targets metabotropic glutamate receptors 2 and 3 (mGlu2, mGlu3). RO4988546 can reduce the binding of [3h]-LY354740 at the positive binding site, while affecting the receptors G protein coupling and intracellular signaling. RO4988546 can be used in the development of antidepressants and cognitive enhancers[1].
Molecular Weight:
512.38
CAS Number:
[911114-85-7]
Formula:
C21H10F6N4O3S
Target:
mGluR
Application Notes:
MCE Product type: Reference compound
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