Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding ''linker-less ADC[1][2][3].
Molekulargewicht:
535.63
Reinheit:
99.71
CAS Nummer:
[1426953-21-0]
Formel:
C28H41NO9
Target-Kategorie:
ADC Payload
Anwendungsbeschreibung:
MCE Product type: ADC Related
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