Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding ''linker-less ADC[1][2][3].
Molecular Weight:
535.63
Purity:
99.71
CAS Number:
[1426953-21-0]
Formula:
C28H41NO9
Target:
ADC Payload
Application Notes:
MCE Product type: ADC Related
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