MRGPRX1 agonist 1 is a highly potent MRGPRX1 agonist (EC50=50 nM) with greater than 50-fold selectivity for delta, µ, and kappa opioid receptors. MRGPRX1 agonist 1 is inactive against MRGPRC11. MRGPRC11 inhibits high voltage-activated (HVA) Ca2+ currents, reduces neurotransmitter release, and mitigates nociceptive transmission in the spinal cord. MRGPRX1 agonist 1 is useful for the study of chronic pain, especially neuropathic pain[1].
Molekulargewicht:
435.50
Reinheit:
99.95
CAS Nummer:
[2377379-39-8]
Formel:
C23H21N3O4S
Target-Kategorie:
Mas-related G-protein-coupled Receptor (MRGPR)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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