iVeliparib-AP6, CAS [[2472645-27-3]] Preis auf Anfrage

Produktübersicht

• Artikelname: iVeliparib-AP6, CAS [[2472645-27-3]] Preis auf Anfrage
• Artikelnummer: MCE-HY-130646
• Hersteller Artikelnummer: HY-130646
• Alternativnummer: MCE-HY-130646-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

iVeliparib-AP6 is a proteolysis-targeting chimera (PROTAC) molecule designed based on Veliparib (HY-10129), which targets PARP1/2. The DC50s of iVeliparib-AP6 for inducing the degradation of PARP1 and PARP2 are 36 nM and 63 nM, respectively, and its IC50s are 69 nM and 21 nM, respectively. iVeliparib-AP6 contains a Veliparib-based PARP inhibitor warhead linked to a CRBN E3 ligase binder, it uses Thalidomide (HY-14658) as a ligand to recruit CRBN E3 ubiquitin ligase and exerts the PARP2 degradation mechanism[1][2].

Produkteigenschaften

• Molekulargewicht: 807.89
• CAS Nummer: [2472645-27-3]
• Formel: C40H53N7O11
• Target-Kategorie: PARP,PROTACs

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound