iVeliparib-AP6, CAS [[2472645-27-3]] Preis auf Anfrage

Product Overview

• Article Name: iVeliparib-AP6, CAS [[2472645-27-3]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-130646
• Supplier Catalog Number: HY-130646
• Alternative Catalog Number: MCE-HY-130646-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

iVeliparib-AP6 is a proteolysis-targeting chimera (PROTAC) molecule designed based on Veliparib (HY-10129), which targets PARP1/2. The DC50s of iVeliparib-AP6 for inducing the degradation of PARP1 and PARP2 are 36 nM and 63 nM, respectively, and its IC50s are 69 nM and 21 nM, respectively. iVeliparib-AP6 contains a Veliparib-based PARP inhibitor warhead linked to a CRBN E3 ligase binder, it uses Thalidomide (HY-14658) as a ligand to recruit CRBN E3 ubiquitin ligase and exerts the PARP2 degradation mechanism[1][2].

Product Properties

• Molecular Weight: 807.89
• CAS Number: [2472645-27-3]
• Formula: C40H53N7O11
• Target: PARP,PROTACs

Application Notes

• Application Notes: MCE Product type: Reference compound