N-Methylmesoporphyrin IX (NMM), a widely used G-quadruplex DNA specific fluorescent binder, is an efficient probe for monitoring Abeta fibrillation. N-Methylmesoporphyrin IX is an in situ inhibitor and an ex situ monitor for Abeta amyloidogenesis both in vitro and in cells. N-Methylmesoporphyrin IX is sensitive to G-quadruplexes DNA but has no response to duplexes, triplexes and single-stranded forms DNA. N-Methylmesoporphyrin IX is nonfluorescent alone or in monomeric Abeta environments, but emits strong fluorescence through stacking with the Abeta assemblies[1].
Molekulargewicht:
580.72
Reinheit:
99.65
CAS Nummer:
[142234-85-3]
Formel:
C35H40N4O4
Target-Kategorie:
G-quadruplex
Anwendungsbeschreibung:
MCE Product type: Dye Reagents
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
