N-Methylmesoporphyrin IX (NMM), a widely used G-quadruplex DNA specific fluorescent binder, is an efficient probe for monitoring Abeta fibrillation. N-Methylmesoporphyrin IX is an in situ inhibitor and an ex situ monitor for Abeta amyloidogenesis both in vitro and in cells. N-Methylmesoporphyrin IX is sensitive to G-quadruplexes DNA but has no response to duplexes, triplexes and single-stranded forms DNA. N-Methylmesoporphyrin IX is nonfluorescent alone or in monomeric Abeta environments, but emits strong fluorescence through stacking with the Abeta assemblies[1].
Molecular Weight:
580.72
Purity:
99.65
CAS Number:
[142234-85-3]
Formula:
C35H40N4O4
Target:
G-quadruplex
Application Notes:
MCE Product type: Dye Reagents
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