AZD3839 is an orally available, selective, reversible inhibitor of the beta-site amyloid precursor protein cleaving enzyme BACE1 that can cross the blood-brain barrier. AZD3839 inhibits recombinant human BACE1 with a Ki=26.1 nM. AZD3839 inhibits A40 production in SH-SY5Y cells with an IC50 of 4.8 nM. AZD3839 binds to BACE1 and reduces the Abeta amyloid produced by the cleavage of amyloid precursor protein (APP) by BACE1 and gamma-secretase. AZD3839 can be used in the field of Alzheimers disease research[1][2][3].
Molekulargewicht:
431.41
Reinheit:
99.97
CAS Nummer:
[1227163-84-9]
Formel:
C24H16F3N5
Target-Kategorie:
Beta-secretase
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
