AZD3839 is an orally available, selective, reversible inhibitor of the beta-site amyloid precursor protein cleaving enzyme BACE1 that can cross the blood-brain barrier. AZD3839 inhibits recombinant human BACE1 with a Ki=26.1 nM. AZD3839 inhibits A40 production in SH-SY5Y cells with an IC50 of 4.8 nM. AZD3839 binds to BACE1 and reduces the Abeta amyloid produced by the cleavage of amyloid precursor protein (APP) by BACE1 and gamma-secretase. AZD3839 can be used in the field of Alzheimers disease research[1][2][3].
Molecular Weight:
431.41
Purity:
99.97
CAS Number:
[1227163-84-9]
Formula:
C24H16F3N5
Target:
Beta-secretase
Application Notes:
MCE Product type: Reference compound
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