ML281, CAS [[1404437-62-2]]

Produktübersicht

• Artikelname: ML281, CAS [[1404437-62-2]]
• Artikelnummer: MCE-HY-13495
• Hersteller Artikelnummer: HY-13495
• Alternativnummer: MCE-HY-13495-100MG,MCE-HY-13495-5MG,MCE-HY-13495-25MG,MCE-HY-13495-10MG,MCE-HY-13495-10MMX1ML,MCE-HY-13495-200MG,MCE-HY-13495-50MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

ML281 is a highly selective inhibitor of serine/threonine kinase 33 (STK33) with an IC50 value of 14 nM. ML281 shows 700-fold selectivity over PKA and 550-fold over AurB. ML281 exerts core mechanism by inhibiting STK33: in small cell lung cancer, ML281 downregulates RPS6/BAD signaling phosphorylation, induces apoptosis, and suppresses proliferation, invasion[1]. ML281 reduces STK33-mediated 4-hydroxyphenylpyruvate dioxygenase (HPD) phosphorylation in tyrosinemia [4]. ML281 is suitable for research on STK33 function, KRAS mutation-related cancers (pancreatic cancer, colon cancer, lung adenocarcinoma, etc.), small cell lung cancer, and tyrosinemia-related damage[1][2][4]

Produkteigenschaften

• Molekulargewicht: 389.47
• Reinheit: 99.91
• CAS Nummer: [1404437-62-2]
• Formel: C22H19N3O2S
• Target-Kategorie: Apoptosis,Aurora Kinase,Bcl-2 Family,PKA,STK33

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound