ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM. ML281 showed a 550-fold selectivity over AurB and greater than 700-fold selectivity over PKA. target: STK33 IC50: 14 nM [1] ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors. Even at the highest concentration tested (10 µM), ML281 had no effect on the viability of KRAS-dependent cancer cells. [2]
Molecular Weight:
389.47
Purity:
99.91
CAS Number:
[1404437-62-2]
Formula:
C22H19N3O2S
Target:
STK33
Application Notes:
MCE Product type: Reference compound
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