RWJ-60475 is a cell-permeable tyrosine phosphatase inhibitor with an IC50 of 3.3 µM. RWJ-60475, by inhibiting the activity of CD45/CD148 phosphatase, interferes with the phagocytic function of macrophages, thereby blocking the invasion of Legionella pneumophila into host cells and the transport of effector proteins. RWJ-60475 significantly reduces the uptake of bacterial particles by macrophages. RWJ-60475 can be used in the research of anti-infection targeting host factors[1][2].
Molekulargewicht:
404.11
CAS Nummer:
[204130-08-5]
Formel:
C13H11BrNO7P
Target-Kategorie:
Bacterial,Phosphatase
Anwendungsbeschreibung:
MCE Product type: Reference compound1
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
