RWJ-60475 is a cell-permeable tyrosine phosphatase inhibitor with an IC50 of 3.3 µM. RWJ-60475, by inhibiting the activity of CD45/CD148 phosphatase, interferes with the phagocytic function of macrophages, thereby blocking the invasion of Legionella pneumophila into host cells and the transport of effector proteins. RWJ-60475 significantly reduces the uptake of bacterial particles by macrophages. RWJ-60475 can be used in the research of anti-infection targeting host factors[1][2].
Molecular Weight:
404.11
CAS Number:
[204130-08-5]
Formula:
C13H11BrNO7P
Target:
Bacterial,Phosphatase
Application Notes:
MCE Product type: Reference compound1
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