I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase alpha (PI5P4Kalpha), with an IC50 of 1 µM[1].
Molekulargewicht:
437.19
Reinheit:
98.03
CAS Nummer:
[1094048-77-7]
Formel:
C17H12INO5
Target-Kategorie:
IGF-1R
Anwendungsbeschreibung:
MCE Product type: Reference compound
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