(1R,9R)-Exatecan (mesylate), CAS [[2938875-39-7]]

Produktübersicht

• Artikelname: (1R,9R)-Exatecan (mesylate), CAS [[2938875-39-7]]
• Artikelnummer: MCE-HY-13631J
• Hersteller Artikelnummer: HY-13631J
• Alternativnummer: MCE-HY-13631J-10MMX1ML,MCE-HY-13631J-100MG,MCE-HY-13631J-25MG,MCE-HY-13631J-500MG,MCE-HY-13631J-5MG,MCE-HY-13631J-10MG,MCE-HY-13631J-50MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: (1R,9R)-DX8951f

Produktbeschreibung

(1R,9R)-Exatecan mesylate ((1R,9R)-DX8951f) is a non-prodrug camptothecin derivative and a potent topoisomerase I inhibitor (IC50=0.975 µg/mL in mice and 0.82 µg/mL in humans). (1R,9R)-Exatecan mesylate blocks enzyme activity and induces apoptosis by stabilizing the enzyme-DNA cleavable complex. (1R,9R)-Exatecan mesylate not only effectively inhibits the proliferation of various malignant tumor cells and tumor growth, but also circumvents P-glycoprotein-mediated multidrug resistance. (1R,9R)-Exatecan mesylate is widely used in preclinical studies of multiple cancers including pancreatic cancer, lung cancer, breast cancer, and leukemia[1][2]. The low-activity isomer of (1R,9R)-Exatecan mesylate is (1S,9R)-Exatecan mesylate (HY-13631I).

Produkteigenschaften

• Molekulargewicht: 531.55
• Reinheit: 99.88
• CAS Nummer: [2938875-39-7]
• Formel: C25H26FN3O7S
• Target-Kategorie: Apoptosis,Drug Derivative,Topoisomerase

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound