(1R,9R)-Exatecan (mesylate), CAS [[2938875-39-7]]

Product Overview

• Article Name: (1R,9R)-Exatecan (mesylate), CAS [[2938875-39-7]]
• Biozol Catalog Number: MCE-HY-13631J
• Supplier Catalog Number: HY-13631J
• Alternative Catalog Number: MCE-HY-13631J-10MMX1ML,MCE-HY-13631J-100MG,MCE-HY-13631J-25MG,MCE-HY-13631J-500MG,MCE-HY-13631J-5MG,MCE-HY-13631J-10MG,MCE-HY-13631J-50MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: (1R,9R)-DX8951f

Product Description

(1R,9R)-Exatecan mesylate ((1R,9R)-DX8951f) is a non-prodrug camptothecin derivative and a potent topoisomerase I inhibitor (IC50=0.975 µg/mL in mice and 0.82 µg/mL in humans). (1R,9R)-Exatecan mesylate blocks enzyme activity and induces apoptosis by stabilizing the enzyme-DNA cleavable complex. (1R,9R)-Exatecan mesylate not only effectively inhibits the proliferation of various malignant tumor cells and tumor growth, but also circumvents P-glycoprotein-mediated multidrug resistance. (1R,9R)-Exatecan mesylate is widely used in preclinical studies of multiple cancers including pancreatic cancer, lung cancer, breast cancer, and leukemia[1][2]. The low-activity isomer of (1R,9R)-Exatecan mesylate is (1S,9R)-Exatecan mesylate (HY-13631I).

Product Properties

• Molecular Weight: 531.55
• Purity: 99.88
• CAS Number: [2938875-39-7]
• Formula: C25H26FN3O7S
• Target: Apoptosis,Drug Derivative,Topoisomerase

Application Notes

• Application Notes: MCE Product type: Reference compound