PI3K-IN-11 (compound 13) is a PI3K inhibitor, which selectively inhibits PI3Kalpha, PI3Kbeta, PI3K, and PI3Kdelta (IC50s=6.4, 13, 8, and 11 nM, respectively) over mTOR (IC50=2.9 µM). PX-13-17OH is greater than 420-fold selective for PI3K in a panel of 20 lipid and protein kinases. PX-13-17OH inhibits phosphorylation of Akt and S6 kinase (S6K) in PTEN-negative U87MG cells when used at concentrations ranging from 0.03 to 1 µg/mL. It inhibits tumor growth in a U87MG mouse xenograft model when administered at doses ranging from 2.5 to 10 mg/kg.
Molekulargewicht:
546.65
CAS Nummer:
[884539-95-1]
Formel:
C29H42N2O8
Target-Kategorie:
PI3K
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
