PI3K-IN-11 (compound 13) is a PI3K inhibitor, which selectively inhibits PI3Kalpha, PI3Kbeta, PI3K, and PI3Kdelta (IC50s=6.4, 13, 8, and 11 nM, respectively) over mTOR (IC50=2.9 µM). PX-13-17OH is greater than 420-fold selective for PI3K in a panel of 20 lipid and protein kinases. PX-13-17OH inhibits phosphorylation of Akt and S6 kinase (S6K) in PTEN-negative U87MG cells when used at concentrations ranging from 0.03 to 1 µg/mL. It inhibits tumor growth in a U87MG mouse xenograft model when administered at doses ranging from 2.5 to 10 mg/kg.
Molecular Weight:
546.65
CAS Number:
[884539-95-1]
Formula:
C29H42N2O8
Target:
PI3K
Application Notes:
MCE Product type: Reference compound
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