Ingenol 3,20-dibenzoate is a potent protein kinase C (PKC) isoform-selective agonist. Ingenol 3,20-dibenzoate induces selective translocation of nPKC-delta, -epsilon, and -theta and PKC-mu from the cytosolic fraction to the particulate fraction and induces morphologically typical apoptosis through de novo synthesis of macromolecules. Ingenol 3,20-dibenzoate increases the IFN-gamma production and degranulation by NK cells, especially when NK cells are stimulated by NSCLC cells[1][2].
Molekulargewicht:
556.65
Reinheit:
99.96
CAS Nummer:
[59086-90-7]
Formel:
C34H36O7
Target-Kategorie:
Apoptosis,PKC
Anwendungsbeschreibung:
MCE Product type: Natural Products
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