ARN-21934 is a potent, highly selective, blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II alpha over beta. ARN-21934 inhibits DNA relaxation with an IC50 of 2 µM as compared to the anticancer agent Etoposide (IC50=120 µM). ARN-21934 exhibits a favorable in vivo pharmacokinetic profile and is a promising lead compound for anticancer research[1].
Molekulargewicht:
360.46
Reinheit:
98.08
CAS Nummer:
[2230854-93-8]
Formel:
C21H24N6
Target-Kategorie:
Topoisomerase
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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