ARN-21934 is a potent, highly selective, blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II alpha over beta. ARN-21934 inhibits DNA relaxation with an IC50 of 2 µM as compared to the anticancer agent Etoposide (IC50=120 µM). ARN-21934 exhibits a favorable in vivo pharmacokinetic profile and is a promising lead compound for anticancer research[1].
Molecular Weight:
360.46
Purity:
98.08
CAS Number:
[2230854-93-8]
Formula:
C21H24N6
Target:
Topoisomerase
Application Notes:
MCE Product type: Reference compound1
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