KRAS inhibitor-9, a potent KRAS inhibitor (Kd=92 µM), blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 binds to KRAS G12D, KRAS G12C and KRAS Q61H protein with a moderate binding affinity. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells[1].
Molekulargewicht:
292.81
Reinheit:
99.85
CAS Nummer:
[300809-71-6]
Formel:
C13H9ClN2S2
Target-Kategorie:
Apoptosis,Ras
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
