KRAS inhibitor-9, a potent KRAS inhibitor (Kd=92 µM), blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 binds to KRAS G12D, KRAS G12C and KRAS Q61H protein with a moderate binding affinity. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells[1].
Molecular Weight:
292.81
Purity:
99.85
CAS Number:
[300809-71-6]
Formula:
C13H9ClN2S2
Target:
Apoptosis,Ras
Application Notes:
MCE Product type: Reference compound
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