LC-2, CAS [[2502156-03-6]]

Produktübersicht

• Artikelname: LC-2, CAS [[2502156-03-6]]
• Artikelnummer: MCE-HY-137516
• Hersteller Artikelnummer: HY-137516
• Alternativnummer: MCE-HY-137516-10MMX1ML,MCE-HY-137516-100MG,MCE-HY-137516-50MG,MCE-HY-137516-25MG,MCE-HY-137516-10MG,MCE-HY-137516-5MG,MCE-HY-137516-1MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

LC-2 is a potent and first-in-class von Hippel-Lindau-based PROTAC capable of degrading endogenous KRAS G12C, with DC50s between 0.25 and 0.76 µM[1]. LC-2 covalently binds KRAS G12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRAS G12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRAS G12C cell lines[2].

Produkteigenschaften

• Molekulargewicht: 1132.78
• Reinheit: 98.48
• CAS Nummer: [2502156-03-6]
• Formel: C59H71ClFN11O7S
• Target-Kategorie: PROTACs,Ras

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound1