LC-2 is a potent and first-in-class von Hippel-Lindau-based PROTAC capable of degrading endogenous KRAS G12C, with DC50s between 0.25 and 0.76 µM[1]. LC-2 covalently binds KRAS G12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRAS G12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRAS G12C cell lines[2].
Molecular Weight:
1132.78
Purity:
98.48
CAS Number:
[2502156-03-6]
Formula:
C59H71ClFN11O7S
Target:
PROTACs,Ras
Application Notes:
MCE Product type: Reference compound1
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