Guanosine 5-O-(2-thiodiphosphate) trisodium (GDPbetaS trisodium) is a non-hydrolyzable derivative of GDP. Guanosine 5-O-(2-thiodiphosphate) trisodium acts as an inhibitor of adenylyl cyclase (AC) with a Ki value of 600 nM. In the absence of glutamic-pyruvic transaminase (GPT) in cerebral cortex membranes of rodent models, Guanosine 5-O-(2-thiodiphosphate) trisodium partially activates AC with an EC50 of 400 nM. Guanosine 5-O-(2-thiodiphosphate) trisodium prevents norepinephrine-induced nitric oxide release in ventricular myocytes[1][2][3].
Molekulargewicht:
525.21
Reinheit:
97.11
Formel:
C10H12N5Na3O10P2S
Target-Kategorie:
Adenylate Cyclase
Anwendungsbeschreibung:
MCE Product type: Reference compound1
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
