Guanosine 5-O-(2-thiodiphosphate) trisodium (GDPbetaS trisodium) is a non-hydrolyzable derivative of GDP. Guanosine 5-O-(2-thiodiphosphate) trisodium acts as an inhibitor of adenylyl cyclase (AC) with a Ki value of 600 nM. In the absence of glutamic-pyruvic transaminase (GPT) in cerebral cortex membranes of rodent models, Guanosine 5-O-(2-thiodiphosphate) trisodium partially activates AC with an EC50 of 400 nM. Guanosine 5-O-(2-thiodiphosphate) trisodium prevents norepinephrine-induced nitric oxide release in ventricular myocytes[1][2][3].
Molecular Weight:
525.21
Purity:
97.11
Formula:
C10H12N5Na3O10P2S
Target:
Adenylate Cyclase
Application Notes:
MCE Product type: Reference compound1
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