XL019, CAS [[945755-56-6]]

Produktübersicht

• Artikelname: XL019, CAS [[945755-56-6]]
• Artikelnummer: MCE-HY-13775
• Hersteller Artikelnummer: HY-13775
• Alternativnummer: MCE-HY-13775-10MG,MCE-HY-13775-5MG,MCE-HY-13775-10MMX1ML
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

XL019 is a potent, orally active, and selective JAK2 inhibitor, with IC50s of 2.2, 134.3, and 214.2 nM for JAK2, JAK1 and JAK3, respectively. XL019 shows 50-fold or greater selectivity for JAK2, versus a panel of over 100 serine/threonine and tyrosine kinases, including other members of the JAK family. XL019 potently inhibits STAT3 and STAT5 phosphorylation in cells harboring either JAK2V617F or wild-type JAK2[1][2].

Produkteigenschaften

• Molekulargewicht: 444.53
• Reinheit: 99.65
• CAS Nummer: [945755-56-6]
• Formel: C25H28N6O2
• Target-Kategorie: Apoptosis,JAK

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound1