XL019 is a potent, orally active, and selective JAK2 inhibitor, with IC50s of 2.2, 134.3, and 214.2 nM for JAK2, JAK1 and JAK3, respectively. XL019 shows 50-fold or greater selectivity for JAK2, versus a panel of over 100 serine/threonine and tyrosine kinases, including other members of the JAK family. XL019 potently inhibits STAT3 and STAT5 phosphorylation in cells harboring either JAK2V617F or wild-type JAK2[1][2].
Molecular Weight:
444.53
Purity:
99.65
CAS Number:
[945755-56-6]
Formula:
C25H28N6O2
Target:
Apoptosis,JAK
Application Notes:
MCE Product type: Reference compound
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