Lufotrelvir (PF-07304814), a phosphate proagent of PF-00835231, acts as a potent 3CLpro protease (Mpro) inhibitor with SARS-CoV-2 antiviral activity. Lufotrelvir binds and inhibits SARS-CoV-2 3CLpro activity with a Ki of 174nM. Lufotrelvir is promising single antiviral agent and also can be used for the research of combination with other antivirals that target other critical stages of the coronavirus life cycle.
Molekulargewicht:
552.51
Reinheit:
99.87
CAS Nummer:
[2468015-78-1]
Formel:
C24H33N4O9P
Target-Kategorie:
SARS-CoV
Anwendungsbeschreibung:
MCE Product type: Reference compound
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