PROTAC BRD4 Degrader linker conjugate is a linker-payload conjugate as well as a bifunctional degrader of BRD4 that binds to VHL, consisting of PROTAC and a linker. PROTAC BRD4 Degrader linker conjugate can be conjugated with STEAP1 and CLL1 antibodies to degrade BRD4 protein, with DC50 values of 0.86 nM and 7.6 nM, respectively. PROTAC BRD4 Degrader linker conjugate can be used in research related to prostate cancer and acute myeloid leukemia (BRD4 ligand: (HY-129939), VHL ligand: (HY-125845))[1].
Molekulargewicht:
1312.50
Reinheit:
98.98
CAS Nummer:
[2417370-42-2]
Formel:
C59H71F2N9O15S4
Target-Kategorie:
Epigenetic Reader Domain,PROTAC-Linker Conjugates for PAC,PROTACs
Anwendungsbeschreibung:
MCE Product type: ADC Related
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