(Rac)-Vepdegestrant, CAS [[2229711-08-2]] Preis auf Anfrage

Produktübersicht

• Artikelname: (Rac)-Vepdegestrant, CAS [[2229711-08-2]] Preis auf Anfrage
• Artikelnummer: MCE-HY-138642A
• Hersteller Artikelnummer: HY-138642A
• Alternativnummer: MCE-HY-138642A-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: (Rac)-ARV-471

Produktbeschreibung

(Rac)-Vepdegestrant is the isomer of Vepdegestrant (HY-138642). Vepdegestrant ((R)-Lavandulol) is an orally active PROTAC estrogen receptor degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC50) of about 2 nM[1].

Produkteigenschaften

• Molekulargewicht: 723.90
• CAS Nummer: [2229711-08-2]
• Formel: C45H49N5O4
• Target-Kategorie: Estrogen Receptor/ERR,PROTACs

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound