C004019 is a BBB-penetrable and small-molecule PROTAC that targets tau. C004019 can simultaneously recruit tau and E3 ligase, and effectively clear tau proteins by promoting the ubiquitination and proteasome-dependent degradation of tau, thereby improving synaptic and cognitive functions in Alzheimers disease (AD) mice. C004019 can be used in the research of AD and tau protein-related diseases. (Pink: Ligand for target protein (HY-138679), Black: linker (HY-140189), Blue: E3 Ligase Ligand (HY-138678))[1]
Molekulargewicht:
1035.29
Reinheit:
99.72
CAS Nummer:
[2417159-57-8]
Formel:
C49H70N12O9S2
Target-Kategorie:
PROTACs,Tau Protein
Anwendungsbeschreibung:
MCE Product type: Reference compound1
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
