C004019 is a BBB-penetrable and small-molecule PROTAC that targets tau. C004019 can simultaneously recruit tau and E3 ligase, and effectively clear tau proteins by promoting the ubiquitination and proteasome-dependent degradation of tau, thereby improving synaptic and cognitive functions in Alzheimers disease (AD) mice. C004019 can be used in the research of AD and tau protein-related diseases. (Pink: Ligand for target protein (HY-138679), Black: linker (HY-140189), Blue: E3 Ligase Ligand (HY-138678))[1]
Molecular Weight:
1035.29
Purity:
99.72
CAS Number:
[2417159-57-8]
Formula:
C49H70N12O9S2
Target:
PROTACs,Tau Protein
Application Notes:
MCE Product type: Reference compound1
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