Ro 31-8220, CAS [[125314-64-9]] Preis auf Anfrage

Produktübersicht

• Artikelname: Ro 31-8220, CAS [[125314-64-9]] Preis auf Anfrage
• Artikelnummer: MCE-HY-13866A
• Hersteller Artikelnummer: HY-13866A
• Alternativnummer: MCE-HY-13866A-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: Bisindolylmaleimide IX

Produktbeschreibung

Ro 31-8220 is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCalpha, PKCbetaI, PKCbetaII, PKCgamma, PKCepsilon and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3beta (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7. Ro 31-8220 can also inhibit the expression of MKP-1, induce the expression of c-Jun, and activate JNK, and these effects possess pharmacological properties independent of PKC[1][2][3][4][5].

Produkteigenschaften

• Molekulargewicht: 457.55
• CAS Nummer: [125314-64-9]
• Formel: C25H23N5O2S
• Target-Kategorie: JNK,PKC

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound1