Ro 31-8220 is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCalpha, PKCbetaI, PKCbetaII, PKCgamma, PKCepsilon and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3beta (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7. Ro 31-8220 can also inhibit the expression of MKP-1, induce the expression of c-Jun, and activate JNK, and these effects possess pharmacological properties independent of PKC[1][2][3][4][5].
Molecular Weight:
457.55
CAS Number:
[125314-64-9]
Formula:
C25H23N5O2S
Target:
JNK,PKC
Application Notes:
MCE Product type: Reference compound1
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