XL177A, CAS [[2417089-74-6]]

Produktübersicht

• Artikelname: XL177A, CAS [[2417089-74-6]]
• Artikelnummer: MCE-HY-138794
• Hersteller Artikelnummer: HY-138794
• Alternativnummer: MCE-HY-138794-25MG,MCE-HY-138794-50MG,MCE-HY-138794-100MG,MCE-HY-138794-1MG,MCE-HY-138794-10MMX1ML,MCE-HY-138794-5MG,MCE-HY-138794-10MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

XL177A is a covalent USP7 inhibitor that blocks the deubiquitinase activity of USP7. XL177A destabilizes non-canonical PRC1 complexes or KDM6A and reduces chromatin deposition of H2AK119Ub, thereby relieving the repression of neuronal differentiation programs. Meanwhile, XL177A also regulates the ELOF1-UVSSA-USP7-nuclear beta-catenin axis, decreasing the transcription levels of related proteins and the accumulation of nuclear beta-catenin. XL177A exerts antiviral effects by reducing the expression levels of coronavirus receptors, and exhibits inhibitory activity against APC-mutated colorectal cancer cells, neuroblastoma, and coronaviruses including SARS-CoV-2 variants. XL177A is mainly used in studies related to colorectal cancer, neuroblastoma, and coronavirus infections[1][2][3][4].

Produkteigenschaften

• Molekulargewicht: 861.47
• Reinheit: 99.60
• CAS Nummer: [2417089-74-6]
• Formel: C48H57ClN8O5
• Target-Kategorie: Deubiquitinase,Histone Demethylase,SARS-CoV

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound