XL177A is a covalent USP7 inhibitor that blocks the deubiquitinase activity of USP7. XL177A destabilizes non-canonical PRC1 complexes or KDM6A and reduces chromatin deposition of H2AK119Ub, thereby relieving the repression of neuronal differentiation programs. Meanwhile, XL177A also regulates the ELOF1-UVSSA-USP7-nuclear beta-catenin axis, decreasing the transcription levels of related proteins and the accumulation of nuclear beta-catenin. XL177A exerts antiviral effects by reducing the expression levels of coronavirus receptors, and exhibits inhibitory activity against APC-mutated colorectal cancer cells, neuroblastoma, and coronaviruses including SARS-CoV-2 variants. XL177A is mainly used in studies related to colorectal cancer, neuroblastoma, and coronavirus infections[1][2][3][4].
Molecular Weight:
861.47
Purity:
99.60
CAS Number:
[2417089-74-6]
Formula:
C48H57ClN8O5
Target:
Deubiquitinase,Histone Demethylase,SARS-CoV
Application Notes:
MCE Product type: Reference compound
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