JB170, CAS [[2705844-82-0]]

Produktübersicht

• Artikelname: JB170, CAS [[2705844-82-0]]
• Artikelnummer: MCE-HY-141512
• Hersteller Artikelnummer: HY-141512
• Alternativnummer: MCE-HY-141512-5MG,MCE-HY-141512-10MG,MCE-HY-141512-25MG,MCE-HY-141512-100MG,MCE-HY-141512-50MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

JB170 is a potent and highly specific PROTAC-mediated AURORA-A (Aurora Kinase) degrader (DC50=28 nM) by linking Alisertib, to the Cereblon-binding molecule Thalidomide. JB170 preferentially binds AURORA-A (EC50=193 nM) over AURORA-B (EC50=1.4 µM). JB170-mediated S-phase arrest is caused specifically by AURORA-A depletion. JB170 has excellent ability to inhibit non-catalytic function of AURORA-A kinase[1].

Produkteigenschaften

• Molekulargewicht: 963.36
• Reinheit: 98.97
• CAS Nummer: [2705844-82-0]
• Formel: C48H44ClFN8O11
• Target-Kategorie: Aurora Kinase,PROTACs

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound