JB170, CAS [[2705844-82-0]]

Product Overview

• Article Name: JB170, CAS [[2705844-82-0]]
• Biozol Catalog Number: MCE-HY-141512
• Supplier Catalog Number: HY-141512
• Alternative Catalog Number: MCE-HY-141512-5MG,MCE-HY-141512-10MG,MCE-HY-141512-25MG,MCE-HY-141512-100MG,MCE-HY-141512-50MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

JB170 is a potent and highly specific PROTAC-mediated AURORA-A (Aurora Kinase) degrader (DC50=28 nM) by linking Alisertib, to the Cereblon-binding molecule Thalidomide. JB170 preferentially binds AURORA-A (EC50=193 nM) over AURORA-B (EC50=1.4 µM). JB170-mediated S-phase arrest is caused specifically by AURORA-A depletion. JB170 has excellent ability to inhibit non-catalytic function of AURORA-A kinase[1].

Product Properties

• Molecular Weight: 963.36
• Purity: 98.97
• CAS Number: [2705844-82-0]
• Formula: C48H44ClFN8O11
• Target: Aurora Kinase,PROTACs

Application Notes

• Application Notes: MCE Product type: Reference compound