MS154 is a first-in-class E3 ligase cereblon-recruited EGFR degrader with Kd values of 1.8 nM and 3.8 nM for EGFR WT and EGFR L858R mutant, respectively. MS154 potently induces degradation of mutant, but not wild-type, EGFR in cancer cell lines in an E3 ligase-dependent manner. MS154 exhibits anticancer effects against lung cancer (blue: E3 ligase ligand (HY-103596), black: linker (HY-W096167), pink: EGFR ligand (HY-168305))[1].
Molekulargewicht:
901.42
Reinheit:
99.71
CAS Nummer:
[2550393-21-8]
Formel:
C46H54ClFN8O8
Target-Kategorie:
EGFR,PROTACs
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
