AK-778-XXMU is a potent DNA binding inhibitor 2 (ID2) antagonist with a KD of 129 nM. AK-778-XXMU can inhibit cell migration and invasion of glioma cell lines, induce apoptosis, and exhibits significant cancer-suppressing potency. AK-778-XXMU inhibits the ID2-KDR signaling axis, thereby down-regulating the downstream angiogenic factors (VEGFA) and invasion-related proteins (MMP2/9), and up-regulating the tumor suppressor factor (PTEN). AK-778-XXMU can be used for the study of glioma[1].
Molekulargewicht:
392.83
Reinheit:
99.96
CAS Nummer:
[1227045-76-2]
Formel:
C22H17ClN2O3
Target-Kategorie:
Apoptosis,MMP,PTEN,VEGFR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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