SHP2-D26 is a first, potent and effective SHP2 PROTAC degrader. SHP2-D26 induces SHP2 degradation requires binding to VHL-1 and SHP2 proteins. SHP2-D26 is also neddylation- and proteasome-dependent. SHP2-D26 can be used for the study of esophageal cancer and acute myeloid leukemia (Pink: SHP2 ligand (HY-176797), Blue: VHL ligand (HY-150803), Black: linker)[1].
Molekulargewicht:
1115.89
Reinheit:
95.83
CAS Nummer:
[2458219-65-1]
Formel:
C56H79ClN12O6S2
Target-Kategorie:
Phosphatase,PROTACs,SHP2
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten